||In terms of food safety, the focus was primarily on the study of the effects of mycotoxins on the biological activity of the cells of animals. Recently, it is beginning to examine the effect of mycotoxins on the plant, particularly the agronomically interesting. The project aims to physiological, biochemical and molecular analysis of basal cell mechanisms of tobacco plants exposed to different fusariotoxins. We will follow anatomic changes in elicited cells, the role of active oxygen species in the process of perception and pharmacological modulation of the responses to mycotoxins elicitation. We will focus on a comparative analysis of regulatory and signaling cascades involved in the response of cells to various fusariotoxins. We will monitor the expression of genes and proteins, as well as the activity of enzymes responsible for the activation, regulation and control of cell response to mycotoxins, which will bring new insights into understanding the principle mechanisms in respect to biotic stress.